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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically characterized by a focus on the practical aspects of the study design, including the recruitment process and consent, adherence, and the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographical regions. This type of heterogeneity is essential for practical trials to be valid, and it also helps reduce bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market, 프라그마틱 슬롯버프 offers various classic table games, including Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta provide customers with an authentic gambling experience, as well as a broad range of virtual betting options. The company has also created various interactive games to make gambling online enjoyable. Some of these shows have a live host, while others are hosted by prominent personalities from the industry.

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Pragmatic Play, a young player in the industry of casinos on the internet, has gained an enviable reputation for its mobile-friendly slot machines. Their games are optimized for mobile devices and are powered by HTML5 technology. They are also regulated and certified by trusted gaming authorities, which ensure fairness and transparency. This is a great signal for players since it indicates that the games have been tested and validated to ensure randomness and unbiased results of every round.

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Legality

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually requested by practitioners and policy makers to inform their decision making. They are also a good way to identify the cause-effect relationship between an intervention and its results. However, they should not, be used to replace explanatory studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.